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Building a Better DNA Assembly Line [Contributions]
Building a Better DNA Assembly Line [Contributions]

Arzeda leverages technology from TeselaGen, Labcyte, and Twist Bioscience to accelerate their synthetic biology workflow.

Written by Eduardo Abeliuk
Updated over a week ago

TeselaGen has developed a deep learning solution to support rapid, precise and accurate DNA-assembly and modification. TeselaGen’s cloud-based platform bridges the gap between good ideas and valuable products like vaccines, biologic medicines and sustainably sourced chemicals.

One example of how TeselaGen can be used to streamline the synthetic biology workflow is given by one of our clients, Arzeda needs to generate their plasmids as efficiently as possible, which often requires reusing fragments to assemble closely related DNA sequences. TeselaGen’s software determines how to best put the plasmids together and which DNA fragments should be synthesized by Twist, automating the process of DNA assembly and nearly guaranteeing successful plasmid construction. 

Once Twist has delivered the DNA fragments, Arzeda uses TeselaGen’s secure, cloud-based software to write detailed instructions for the Echo Liquid Handler to transfer specific volumes of resuspended DNA fragments to the appropriate destination wells, setting up miniaturized DNA assembly reactions. 

TeselaGen’s BUILD app knows exactly which Twist fragments it needs to add together to get the desired results. The process is incredibly fast and almost entirely automated. It takes about five minutes to generate the worklist instructions and import the resulting CSV file to the Echo Liquid Handler’s control software. 

This rational approach makes the process more predictable. Fewer mistakes means Arzeda spends less time circling back to rework plasmids, reducing wasted design and synthesis time. TeselaGen’s software was the glue that binds these processes together.

See the complete case study in this link from TwistBioScience.

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